MLB The Show 22 is a   by  and published by , based on  (MLB). It was released for the  , , and , as well as , a first for the franchise. The seventeenth entry of the  franchise, it was released on April 5, 2022.    is featured as the cover star. A special manga style art by  of Shohei Ohtani is featured on the cover art for the MVP and Digital Deluxe editions of MLB The Show 22.

For the second consecutive year, the Xbox versions of the game are available for  subscribers at no additional cost. People who purchased the MVP or Digital Deluxe editions received early access to the game starting April 1.

It marked one of the first MLB The Show games without any competitors in the United States, either simulation or arcade, as the  series ended due to the Switch getting a port, although in Japan, the sole competitor is the latest entry to the  series from Konami, eBaseball Powerful Pro Yakyuu 2022. gave the game 7/10, praising the gameplay and expansion to various game modes but criticized the lack of innovation elsewhere and repetitive commentary. In its 4/5 review,  similarly complimented the addition to the March to October mode but lamented the limited additions otherwise, saying: "Gripes aside, MLB The Show 22 remains a fun, authentic and comprehensive simulation, among the industry's best. Ignoring the surrounding marketplace pressure to reiterate and innovate, Sony's series sits alongside  as the premier pro sports offering." In its 7/10 review,  wrote, "MLB The Show 22 is mostly a retread of an already great game, but more bugs than usual and the not quite ready for primetime co-op mode are signs this series may be losing some velocity."  noted that while MLB The Show 22's core gameplay was solid, it was becoming stale. The site also criticized the game's technical issues, writing, "A week after launch, MLB The Show 22's online performance is shaky...Online stability continues to be a huge hole...While the new Switch iteration offers all the content of the PlayStation and Xbox versions, it suffers from framerate stuttering and significant graphical flickering."  and  praised the gameplay, seasons, , and streamlined format while panning the unimproved visuals, aging game modes, and repetitive commentary. Several review outlets noted that while the Switch version suffered from major technical issues such as framerate stutters and scaled back visuals, it was still playable and fun.